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Treatment Resistant Bipolar Depression

This Task Force will address the definition of treatment resistant bipolar depression and provide guidance on clinical trial design, methodology, and optimal endpoints for regulatory bodies, investigators and clinicians, to improve awareness, advance science, and deliver better treatments for this condition.

Objectives

  1. Coming soon!

Leads

Portrait of an older man with gray hair and beard, red glasses, wearing a burgundy shirt and brown blazer outdoors, looking at the camera.

Eduard Vieta,
Spain

Members of Task Force

Ana Andreazza, Canada

Gerard Anmella, Spain

Horizontal black-red-gold tricolor flag representing Germany.

Michael Bauer, Germany

Australian flag: blue field with Union Jack in the canton, a large white Commonwealth Star, and the Southern Cross constellation of white stars on the right.

Michael Berk, Australia

Uganda flag with black, yellow, and red horizontal stripes and a white disk containing a crowned crane in the center.

Harriet Birabwa-Oketcho, Uganda

Flag of Italy: vertical green, white, and red stripes from left to right.

Paolo Brambilla, Italy

Flag of Poland: white on top, red on the bottom

Wieslaw J. Cubala, Poland

Australian flag: blue field with Union Jack in the canton, a large white Commonwealth Star, and the Southern Cross constellation of white stars on the right.

Olivia Dean, Australia

Giovanna Fico, Spain

Brisa Frenandes, USA

Ana Gonzalez-Pinto, Spain

Kyooseob Ha, Canada/South Korea

Vertical tricolor flag of France: blue, white, and red bands from left to right.

Chantal Henry, France

Diego Hidalgo-Mazzei, Spain

Flag of Colombia: yellow top half with blue and red stripes below (three horizontal stripes).

Carlos Lopez-Jaramillo, Colombia

Roger McIntyre, Canada

Kamilla Miskowiak, Denmark

Andrew Nierenberg, USA

Paula Nunes, Canada/Brazil

Aysegul Ozerdem, USA

Isabella Pacchiarotti, Spain

Flag of Serbia: red-blue-white tricolor with the national coat of arms and crown centered

Maja Pantovic Stefanovic, Serbia

Robert Post, USA

Balwinder Singh, USA

Jair Soares, USA

Trisha Suppes, USA

Holly Swartz, USA

Mauricio Tohen, USA

Australian flag: blue field with Union Jack in the canton, a large white Commonwealth Star, and the Southern Cross constellation of white stars on the right.

Tamsyn Van Rheenen, Australia

Lakshmi Yatham, Canada

Flag of the United Kingdom (Union Jack) with red, white, and blue cross design across a blue field.

Allan Young, UK

Task Force Updates

Publications: 

2025

Vieta, E., McIntyre, R.S., Suppes, T., Van Rheenen, T.E., Singh, B., Miskowiak, K.W., Young, A.H., Yatham, L.N., Ha, K., Berk, M., Swartz, H.A., Henry, C., Stefanovic, M.P., Diaz, G.A., Ozerdem, A., Cubała, W.J., Hidalgo-Mazzei, D., Tohen, M., Pacchiarotti, I., Nunes, P.V., Lopez-Jaramillo, C., Gonzalez-Pinto, A., Brambilla, P., Post, R., Soares, J.C., Bauer, M., Andreazza, A.C., Fradera, X.J., Cosials-Lopez, M. and Fico, G. (2025), Defining Treatment-Resistant Bipolar Depression: Recommendations From the ISBD Task Force. Bipolar Disord, 27: 411-423.

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